Wiesje van der Flier

Prediction session11.30-13.00


Wiesje van der Flier (1975) is full professor and head of clinical research at the Alzheimer center Amsterdam at Amsterdam UMC, the Netherlands, where she has worked since 2004. She studied neuropsychology at the University of Utrecht. In addition, she is a clinical epidemiologist. She leads the Amsterdam Dementia Cohort, an ongoing memory-clinic based cohort including over 6000 patients with deep phenotyping (MRI, EEG, CSF biomarkers, and PET) and linked biobank (blood, DNA, CSF). The Amsterdam Dementia Cohort is the basis for many of the studies performed at the VUmc Alzheimer center. Van der Flier has been (co)promotor of >20 theses and is currently supervising ~10 PhD projects.

Van der Fliers main research areas are phenotypical heterogeneity, early diagnosis and the role of vascular factors in Alzheimer’s disease. Together with colleague Philip Scheltens, she has written a book, het Alzheimermysterie, which was published by the Arbeiderspers (2015). 

Towards individualized risk profiling in patients with mild cognitive impairment 

Among the largest advances in Alzheimer’s disease research are the development of biomarkers such as MRI, CSF and PET that can support the diagnosis by providing evidence of Alzheimer pathophysiology. With the advance of these diagnostic tests however, important questions remain to be answered, such as: how to deal with borderline (ab)normal test results, what if test results are conflicting, and what if the biomarker is abnormal but the patient does not have dementia (yet). Patients with mild cognitive impairment have impaired memory, yet do not fulfill criteria for dementia. On a group level, MCI patients with abnormal biomarkers are more likely to progress to dementia.

In this presentation, I will describe the development of individualized prediction models, that use diagnostic test results (MRI, CSF, PET) to provide a probability of progression to dementia for an individual patient. To facilitate use of these models in clinical practice, we built the ADappt, an online tool with a module for clinicians and a module to communicate the test results to patients.  

Presentation of Wiesje van der Flier (PDF)